While long-term memory appears to be preserved in depressed patients
undergoing maintenance electroconvulsive therapy (ECT), these patients may
suffer short-term memory impairment and frontal function alteration, claim
investigators.

“Memory impairment is the main neuropsychological problem associated with
acute ECT, but the specific subtypes of memory dysfunction associated with
maintenance-ECT remain unknown,” observe Miquel Bernardo (Hospital ClÌnic,
Barcelona, Spain) and colleagues.

To investigate, they assessed memory, attention, and frontal function in 11
patients with depression in remission, who had received an average of 36.1
previous ECT sessions with a mean intersession interval of 52.7 days. These
were compared with 11 age- and sex-matched patients with depression who had
not received ECT.

There was no difference between the two groups with regard to long-term
memory or in attention function.

However, encoding of new information and performance on most tests of
frontal function were significantly impaired in the patients receiving
maintenance ECT. Compared with controls, these patients also showed
alterations in verbal fluency, mental flexibility, working memory, and
visuomotor speed.

Thus, maintenance ECT for patients in this study was characterized by
“normal long-term memory, while frontal functions and short-term memory were
impaired,” say Bernardo et al.

“Further studies are required to establish the cognitive state in patients
during maintenance ECT, as this will help to determine their quality of life
and everyday functioning during treatment,” they conclude in the journal
Psychological Medicine.”

Psychol Med 2003; 33: 345ñ350